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As I elaborate on in my video The Symptoms of Vitamin B12 Deficiency , these include: Abdominal distention Chronic diarrhea Shortness of breath Swollen, red, painful feet Skin darkening Bilateral useless hand syndrome Numbness and tingling in the hands and feet Muscle cramps Dizziness Cognitive disturbances Difficulty walking Erectile dysfunction Fatigue Depression Psychosis Coma Blindness Vitamin B12 Deficiency Treatment Is A Vitamin B12 Shot Better Than Taking B12 Orally

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Moreover, alternative biologic therapies have been explored for AF treatment, including anakinra (an IL-1 receptor antagonist) used alongside bisphosphonates and corticosteroids for AF with severe osteoarticular symptoms (27), ustekinumab (an interleukin (IL)-12/23 inhibitor) (28), and apremilast (a selective inhibitor of phosphodiesterase 4) (29)