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One estimation of the extent of myelination that can be acquired by tNs comes from seminal work by Gaillard et al
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Mice were treated for 12 weeks before being sacrificed
N-acetylcysteine, an efficient thiol antioxidant and GSH precursor, was able to inhibit ATG by impeding the lipidation process of LC3 mediated by ATG4, the activity of which is modulated by hydrogen peroxide (Scherz-Shouval et al., 2007)
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