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With second generation GLP-1 agonists (liraglutide, dulaglutide), emphasis turned to increasing protein binding, reducing renal clearance, thus further prolonging drug half-life to now permit weekly injectable formulations (e.g semaglutide)

Others experience injection fatigue or lifestyle changes that make weekly subcutaneous administration impractical

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Retiro la tapa exterior y luego, la tapa interior