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By stimulating these two hormone pathways simultaneously, tirzepatide regulates appetite, slows gastric emptying, improves insulin sensitivity, and promotes fat mobilization, producing greater, more sustained weight loss than GLP-1-only therapies like semaglutide

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MMP-9 expression, MMP-2/TIMP-1 and MMP-9/TIMP-1 ratio increased markedly (Fig

These observations have contributed to ongoing research interest in the compounds potential interactions with vascular endothelial growth factor pathways

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