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2016;5(2):e002343

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For PLGA microsphere depots, bioequivalence requires both pharmacokinetic similarity and in vitro release profile matching which effectively requires the generic to replicate the polymer architecture as well as the drug release rate

If classified as a generic (rather than a biosimilar likely dependent on whether the drug is synthetic or recombinant), Canadian pricing regulations could require discounts of up to 75% relative to originator products, unlocking new potential for public and private payers to cover the drug at scale

Nutrients, 14 Peng L, Li ZR, Green RS, Holzman IR, Lin J

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