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Application of liraglutide reduced mitochondrial damage by attenuating mitophagy via the protein phosphatase and tensin homolog-induced kinase 1 (PINK1)/Parkin pathway, the most well-known pathway for mitophagy (Figure 3)

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61 Conversely, extracellular metabolites may also restrain propagation by altering membrane lipid composition and reducing ferroptosis susceptibility