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Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation

Light bumps, edge and shelf wear

Even in healthy people, oral B12 absorption is only 5070% bioavailable

A 2025 systematic review in orthopaedic sports medicine noted that most evidence remains preclinical, but the peptide showed promising findings in muscle, tendon, ligament, and bony injury models

Typically administered intramuscularly, ensuring 100% absorption compared to oral supplements that might have reduced bioavailability

Some people report a mild warmth or a light stimulant edge in the first few days, plausibly the MAO-A activity rather than the NNMT effect