Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation
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However, one hypothesis, supported by a research group is that following infection by SARS-CoV-2, somehow the microglia become immunoreactive, and destroy more synapses than normal.Covid19 seems to have a high affinity for the brain 3 4 , however this may not be exclusive to covid and may explain the onset of chronic fatigue and depression, among others, which are triggered by other infectious agents
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