The twelve-weeks-on, four-weeks-off cycle does the same thing on a longer scale, with the goal of keeping the system responsive instead of pushing it continuously
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Skwarska A, Moujalled DM, Panis PF, Zhang Q, Herbrich SM, Kurvilla VM, Baran N, Pomilio G, Halilovic E, Ruvolo PP, Ruvolo V, Morris E, Derreal A, Banquet S, Daver N, Andreeff M , Wei A, Konopleva M
doi: 10.4196/kjpp.2024.28.1.83 203 HuttDMRothDMVignaudHCullinCBouchecareilhM
PubMed laboratory research record [PMID: 16141115] PubMed record related to this compound for laboratory literature review
An enhanced potency is due to the markedly decreased binding of human Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs