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Patients with a history of gastroparesis, severe gastrointestinal disease, or inflammatory bowel disease require careful evaluation, as delayed gastric emptying induced by semaglutide may potentially worsen symptoms or interfere with the absorption of other medications
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"Restarting too soon worsened my constipation - Ill wait longer next time." - u/Cscarbie Some find the appetite suppression almost too effective during the healing phase
Retatrutide hit 28.3% in Phase 3 trials
The safety profile appears favorable for extended use based on available data, though long-term studies specifically on oral formulations do not exist
Here is a snapshot of how they compare on cost and key characteristics: Ozempic is the most affordable option on the PBS for patients with type 2 diabetes, costing approximately $42 per script with the subsidy
