6 Higher doses of oral semaglutide (25 and 50 mg) are under development for the treatment of both obesity and type 2 diabetes
Biochemistry 84, 79100
Consult a registered dietitian if you have chronic kidney disease or other conditions affecting protein requirements
And, as critics have pointed out over the years, by elevating just one, two, or at most, three researchers, the Nobels distort the history of science by personalizing discoveries that are truly made by groups of individuals. That reality hangs heavy especially over a decision about GLP-1 and other gut-hormone based drugs, given how much additional science had to be done to convert the hormones to effective, and then even more effective, drugs
SGLT-2 inhibitors and GLP-1RA represent antihyperglycemic therapies shown to reduce CVD and chronic kidney disease risks in patients with T2D
Seniors who are most medically motivated to start GLP-1 therapy those with severe obesity, established cardiovascular disease, or significant comorbidities are precisely the people who stand to gain the most from sustained treatment and who face the greatest health risk from abrupt discontinuation at the end of 2027