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Formula or method Projected weight = Baseline weight (1 + Percent change from baseline) If already on treatment: Estimated baseline = Current weight (1 + Percent loss at current week) Extrapolated week uses the recent slope from the end of the trial curve Example On the tirzepatide curve, a 100 kg baseline reaches about 78.4 kg by week 72

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These improvements occurred while many participants reduced or eliminated concurrent diabetes medications