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Comparing the oxygen required for the oxidation of different substrates to generate ATP, the oxygen efficiency of glucose is generally considered to be more favourable than that of acetyl-CoA, which is more similar to fatty acids

Glutathione has the following roles in the body: Neutralize free radicals and oxidative stress Reverse damage from radiation (X-rays, CT scans, UV and solar radiation) Detoxify heavy metals Detoxify biotoxins (like mold) Help reverse damage from environmental chemicals and pollution Neutralize toxins from food like charred foods and pesticides Improve liver detox pathways Research has found that the following chronic diseases are associated with a reduction in Glutathione levels: Aging Alzheimers Disease Cancer Chronic Liver Disease Cognitive Impairment Diabetes Hypertension Infertility in Both Men and Women Lupus Mental Health Disorders Multiple Sclerosis Neurodegenerative Disorders Parkinsons Disease Glutathione is made of 3 amino acids: cysteine (a sulfur amino acid), glycine, and glutamic acid

In one study where glutamine was used along with chemoradiotherapy for non-small cell lung cancer, the nutrient did not interfere with treatment efficacy and helped prevent weight loss and unplanned treatment delays (Topkan 2012)

The logic is the synergy between the two pathways

doi: 10.1016/j.plipres.2009.02.001 209 FraserNJHowieJWypijewskiKJFullerW

This mechanistic complementarity explains why combined administration consistently produces supra-additive GH release across diverse experimental models