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Its extended half-life compared to native IGF-1 makes it the preferred analog for protocols requiring sustained IGF-1 receptor engagement

doi: 10.1007/s00125-005-0128-9 49 NishiHHigashiharaTInagiR

The comparison worth paying attention to is retatrutide vs tirzepatide both are Eli Lilly compounds, and tirzepatide only received approval in 2023

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Does not replace a varied diet