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The problem is that translation from rodent models to human outcomes is notoriously unreliable, and we've been burned by promising animal data that didn't pan out in humans more times than anyone wants to count
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The relative activities among ACPC-containing analogues of the two natural GLP-1R agonists were consistent with predictions of our hypothesis: the Gly10( R,R )-ACPC analogue of GLP-1 was ~9-fold more potent than the ( S,S )-ACPC diastereomer, and the Gly4( R,R )-ACPC analogue of exendin-4 was ~5-fold more potent than the ( S,S )-ACPC diastereomer in eliciting cAMP production (Fig
Quick Answer: Tirzepatide does not directly cause anemia according to FDA prescribing information and clinical trial data
It is important to emphasize the distinction between promising rodent studies and clinical relevance in humans
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