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Alternatively, it is possible that the C26 VLCFA facilitates clustering across leaflets, as has been shown for GPI-linked proteins at the plasma membrane (Raghupathy et al., 2015)
The fix: It doesnt have to be
These interactions strengthen the binding and function of GLP-2, consistent with the decreased potencies of R242A (by 5-fold), R242E (by 20-fold), W249A (by 1552-fold) and Y252A (by 5-fold) (Fig
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