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As the study authors state with scientific precision, "Thus, the present results cannot establish the psychiatric safety of tirzepatide for weight management when used by individuals with major psychopathology." The authors' own summary underscores this point: "In this post hoc analysis, tirzepatide relative to placebo was not associated with an increased risk of symptoms of depression

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Your doctor may order kidney function tests to ensure the medication is well-tolerated and does not adversely affect your kidneys