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Metabolic adaptation, the body resetting its energy balance to a lower expenditure level during weight loss, means that the post-treatment metabolic rate is lower than before treatment began

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Constitutive activation of liver kinase B1/AMP-activated protein kinase (LKB1/AMPK) pathway in KO livers The resistance of KO mice to steatosis induced by chronic EtOH consumption suggests low hepatic GSH elicits a protective metabolic adaption in the liver