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& Jia, P
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Annu Rev Pharmacol Toxicol 62:255277
41 The presence and severity of subclinical and clinical target organ damage is associated, in the setting of hypertension, with that of endothelial dysfunction
Correct mutations and sequences were confirmed by sequencing both strands
Patients should: Follow the dose escalation schedule to minimise side effects Attend regular follow-up appointments to monitor progress and safety Engage with dietetic support to ensure adequate nutrition whilst reducing calorie intake Combine medication with increased physical activity (aim for 150 minutes moderate-intensity exercise weekly, plus muscle-strengthening activities on at least 2 days per week, as per UK Chief Medical Officers' guidelines) Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, physical activity, and behavioural strategies
