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GLP-1 Mechanism in Menopause: Appetite, Metabolism, and Energy Balance GLP-1 agonists suppress orexigenic (hunger-promoting) neurons and enhance satiety signals, offsetting the appetite dysregulation that accompanies estrogen decline

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These defects were accompanied by disrupted phosphorylation of the IRS, as well as down-regulated expression of mitochondrial proteins PPAR co-activator 1 (PGC1) and uncoupling protein-2 (UCP-2) [200]

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