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Our body naturally produces glutathione, but factors such as poor diet, stress, and environmental toxins can deplete its levels

These include cationic drugs eliminated by renal tubular secretion (such as cimetidine, dolutegravir, ranolazine, vandetanib, and trimethoprim)

The severity and duration of deficiency are perhaps the most significant factors

doi: 10.1016/j.steroids.2012.10.019

TIMP-1: a key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease

In rare cases, more severe side effects such as irregular heartbeat or trouble breathing may occur