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Statistical analysis was performed using a one-way analysis of variance and was analyzed further by the NewmanKeuls test for significant differences

For those who don't want to wait until 20272028, tirzepatide (Zepbound) currently offers the best available alternative at 22.5% average weight loss

This further leads to the reversal of mitochondrial dysfunction, thereby increasing mitochondrial -oxidation and reducing intracellular oxidative stress to prevent hepatic lipotoxicity (53, 54)

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Prescription phentermine is available where clinically appropriate, and B12 or lipotropic injections are offered as an add-on

Available from Accessed 7 August 2023 Eastwood SV, Tillin T, Sattar N, Forouhi NG, Hughes AD, Chaturvedi N (2015) Associations between prediabetes, by three different diagnostic criteria, and incident CVD differ in South Asians and Europeans