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According to the study by McNeil et al., MrgprX2 is a receptor almost exclusively expressed on mast cells, and it has been shown to cause mast cell activation in response to several chemotherapeutic agents ( Figure 2 Furthermore, considering the low affinity characteristic of the MrgprX2 receptor, we hypothesize that the patient was able to tolerate rechallenge therapy by avoiding the rapid activation of the allergic threshold, thus successfully enduring the retreatment

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183 Metabolites such as -ketoglutarate directly regulate the NAD + /NADH ratio, influencing oxidation-reduction-sensitive signaling pathways

doi: 10.1080/16546628.2017.1361779 61 KimS.ShinY