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Contraindications Not everyone may be a candidate for tirzepatide
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Approval for Diabetes and Weight Management Over the past decade, three GLP-1/GIP receptor agonists liraglutide, semaglutide, and tirzepatide initially approved by the FDA for adults with type 2 diabetes, have also gained FDA approval for chronic weight management in people without diabetes, provided they meet specific criteria: a BMI of 30, or 27 with at least one weight-related condition such as hypertension, dyslipidemia, or type 2 diabetes
This is caused by the fibrous bands, known as septa, beneath the skin
Some mild effects, such as reduced appetite or occasional nausea, may persist longer but are usually manageable
This dual-receptor mechanism is why tirzepatide often produces greater weight loss in clinical trialspatients experience suppression across multiple metabolic checkpoints rather than one
