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The clinical data gap should be interpreted cautiously given the difference in trial size (338 vs 2,539 participants) and development stage
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Acetaldehyde is subsequently transported to the mitochondria, where it is further converted to acetyl coenzyme A (acetyl-CoA)
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Only 5 patients stopped the trial from gastrointestinal side effects and only 5% of the 9mg and 12mg arms had to stop the trial for any adverse events
Eur J Immunol 32:286673, PMID: 12355439 Palomares T, Alonso-Varona A, Alvarez A, Castro B, Calle Y, Bilbao P (1997) Interleukin-2 increases intracellular glutathione levels and reverses the growth inhibiting effects of cyclophosphamide on B16 melanoma cells
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