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However, oral zinc may cause gastrointestinal discomfort, nausea, or poor absorptionespecially during illness

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In practice, microdosing generally refers to one of three approaches: Sub-therapeutic dosing: Using doses below 2.5 mg weekly (often 0.5 mg to 1.5 mg) Extended low-dose maintenance: Staying at the 2.5 mg initiation dose indefinitely rather than escalating Split dosing: Dividing a standard dose into smaller, more frequent administrations (such as splitting a weekly dose into twice-weekly injections ) Each approach produces different pharmacokinetic profiles and potentially different anti-inflammatory effects