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Based on this, further combined detection of circulating markers such as Citrullinated Histone H3 (CitH3) or MPO-DNA complexes has been proven effective in quantifying systemic and pulmonary inflammatory burden and microthrombotic status, thus providing an indispensable non-invasive window for assessing intrapulmonary NETosis intensity and precisely screening populations that would benefit from anti-NETs therapy (116)