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It remains a research compound that some clinics and individuals have begun using despite the lack of regulatory approval
Animals treated with 5-amino-1MQ showed no signs of toxicity, behavioral changes, or adverse effects at therapeutically effective doses
For each analysis, the statistical test used and n for each group are found in Supplemental Tables 2, 3, or 5
Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet
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