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In a two-year randomised, placebo-controlled trial in adults aged 60 to 81, fat-free mass rose by 1.1 kg while the placebo group lost 0.5 kg but the added lean mass did not produce measurable gains in strength or physical function, and fasting blood glucose rose while insulin sensitivity fell (Nass et al., Annals of Internal Medicine , 2008)

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These modifications result in a longer half-life (approximately 2030 hours) and reduced binding to IGF-binding proteins, making it about three times more potent than native IGF-1

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According to public FDA communications, the agency has signaled increased enforcement regarding certain mass-marketed compounded GLP-1 products