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(November 2023)
Histopathological evaluation used a modified Mankin scoring system
Folic acid should be administered concomitantly if needed
When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the B12 dependent enzymes Methylmalonyl Coenzyme A mutase (MUT), and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase
Clinical trial results showed modest and variable weight loss outcomes
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