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This medicine is not recommended for use in pregnant women unless necessary

In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

If nausea, vomiting, or diarrhea remain significant at any dose, hold that dose for an additional two to four weeks before escalating

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