These are collectively referred to as parkinsonism (1), and they are the result of the progressive loss of dopaminergic neurons in substantia nigra (2) along with the formation of Lewy bodies that comprise misfolded -synuclein in the neurons (3)
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J Frailty Aging, 8(3), 154159
Of the 20 papers included for the GLP-1 subsample, three studies included data from healthy participants, 10 included individuals with overweight and obesity, seven included individuals with T2D, four studies investigated GLP-1 in patients with gastric bypass, one included twins, and, one study included individuals with acquired hypothalamic damage
They go through the same review process and are determined to be therapeutically equivalent to their brand-name counterparts