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Stop taking XIGDUO XR and call your healthcare provider or get medical help right away if you get any of the following

If you are already established on metformin and your GI system has adapted, adding tirzepatide at the 2.5 mg starting dose may produce minimal additional GI effects

Simplicity matters to many patients, and the single-use pen design requires no dose dialing and comes ready to inject, reducing the chance of dosing errors

In a separate follow up Phase 2a study over 49 days, the mechanism of improved glycaemia was shown to be a combination of enhanced insulin secretion and delayed gastric emptying (84)

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This decreases inflammatory cell infiltration and protects surrounding tissues from secondary damage 4