tirzepatide conversion to semaglutide Dose-equivalence reference based on pivotal GLP-1/dual-agonist trials: SURMOUNT-1 (tirzepatide/Zepbound, 72 weeks) STEP-1 (subcutaneous semaglutide/Wegovy, 68 weeks) OASIS-4 (oral semaglutide/Wegovy, 64 weeks). For educational comparison only—these are switching from tirzepatide to semaglutide

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Several trial limitations, including the small sample size, limit the interpretation of these preliminary findings, which require validation in a larger trial

Brittany Albright MD, MPH, DABOM If early evidence suggests receptor agonists could reduce cravings and addictive behaviors, what do you think will be the biggest challenge in proving their real-world effectiveness and safety for patients struggling with substance use disorders