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The homeostasis of cerebral iron is tightly regulated through a complex network of transport and storage proteins, involving transferrin (Tf), non-transferrin-bound iron (NTBI), transferrin receptor (TfR1), divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), ferroxidases such as hephaestin (HEPH) and ceruloplasmin (CP), and intracellular storage protein ferritin ( 3+ binds to TfR1 on endothelial cells, is internalized into endosomes, acidified, and subsequently released into the cytosol via DMT1-mediated transport

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Kanaley JA, Colberg SR, Corcoran MH et al (2022) Exercise/physical activity in individuals with type 2 diabetes: a Consensus Statement from the American College of Sports Medicine

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Tirzepatide 2.5mg $238 5.0mg $278 7.5mg $278 10mg $278 12.5mg $278 15mg $278 $238 We included the $79/mo membership fee and $199/mo cost of meds

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The concept of microdosing typically involves starting with doses as low as 0.5 mg to 1.25 mg weekly, which are fractions of the approved 2.5 mg starting dose

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