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Ans: It usually depends on the type of Vitamin C you are using

10.1021/acs.jafc.8b07313 418 SunJ.PengS.YangQ.YangJ.DaiY.XingL

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Diverse roles of mitochondria in immune responses: novel insights into immuno-metabolism

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Specifically, the extrinsic pathway begins with the binding of death receptors, members of the TNFR superfamily such as Fas and DR4/5, to their respective ligands, such as FasL and TRAIL