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Achieving these stringent endpoints, as outlined in the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) consensus ( Research into mucosal healing has highlighted pathways involving interleukin-20 (IL-20), claudin-2 (CLDN2), and notoginsenoside R1 (NGR1) ( Figure 1 illustrates the differences in immune cell distribution within the intestinal crypts under homeostatic conditions compared with the inflammatory microenvironments of CD and UC
Recent Findings Originally developed for glycemic control in T2DM, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are now being utilized for a range of additional diseases and conditions
Fuselier et al., 2022)
Unlike Ribupatide, Retatrutide is a triple agonist targeting: GLP-1 receptors GIP receptors glucagon receptors Retatrutide has generated significant interest because triple agonist therapies may potentially produce even greater metabolic and weight-loss effects
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