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Its continued use in laboratory investigations has contributed to a substantial body of research focused on peptide-mediated signalling mechanisms

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Advancements in stem cell therapy, namely pancreatic islet transplantation, have been noted, with recent trials demonstrating insulin independence in 60% of recipients after five years

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Contrariwise, other relevant aspects, such as the safety profile and tolerability of GLP-1RA or the beneficial effects on fertility in PCOS, have been more extensively treated, especially considering that possible direct or indirect reproductive effects of GLP-1 RA might require a concomitant effective contraception and a washout period before pregnancy [22, 24,25,26,27,28,29,30,31]