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Efficacy in Adults with Type 2 Diabetes Adults with type 2 diabetes (T2D) respond differently to weight-loss medications depending on beta-cell reserve and baseline HbA1c
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( E ) DPP4 activity
A systematic review and meta-analysis published in Diabetes, Obesity and Metabolism examined cardiovascular outcome trials involving over 60,000 patients treated with GLP-1 receptor agonists
Similar results were observed with another once-weekly GLP-1RA (exenatide), in which subgroup analyses showed a consistent reduction in MACE across a range of baseline characteristics, including gender, age, and previous CV events [29]
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