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The exact mechanisms behind this response are not fully understood, but it is believed that caffeine can influence hormones such as ghrelin and leptin, which regulate hunger and satiety

Brain Res Brain Res Rev 23(12):134143 Mnch G, Schinzel R, Loske C, Wong A, Durany N, Li JJ, Vlassara H, Smith MA, Perry G, Riederer P (1998) Alzheimers diseasesynergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

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Of greater clinical significance are potential safety concerns that require further investigation in larger trials: Heart rate elevation glucagon is known to have chronotropic effects, and increases in resting heart rate were observed in some trial participants

For others, it may be lowering the dose to reduce side effects, cost, or treatment burden