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Clinical Manifestations of Vitamin B12 Deficiency Although the classic hematologic expression of vitamin B 12 deficiency is a megaloblastic macrocytic anemia characterized by an elevated mean corpuscular volume and mean corpuscular hemoglobin, and a peripheral smear containing macroovalocytes and hypersegmented neutrophils, up to 28 percent of affected patients may have a normal hemoglobin level, and up to 17 percent may have a normal mean corpuscular volume

Ethics declarations Competing interests We disclose the following potential conflicts of interest regarding the publication of this manuscript: This research was partly funded by Cleara Biotech

doi: 10.1016/j.ejcb.2024.151450, 17