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[7] [8] Patients with uncontrolled or symptomatic arrhythmias, particularly atrial fibrillation with rapid ventricular response or ventricular arrhythmias, should have these conditions optimized before starting tirzepatide

Three subjects were excluded from all AUC 024h and C max Day 10 analyses: two withdrew from the trial before the 10th dose (one subject in each of the 2 hnight and night30 min treatment arms as described above) and one subject had an incomplete Day 10 pharmacokinetic profile (6 h30 min treatment arm)

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VIP delivery challenges The main limitation of VIP as a therapeutic peptide is its extremely short plasma half-life

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