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Integrating UGT inhibition data into the rule-of-two model significantly enhances the prediction accuracy for drug-induced liver injury (DILI) (119)

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The successful nose-to-brain delivery achieved by chitosomes holds significant broader impact for neurological disorders, offering a blueprint for repurposing other poorly brain-permeable therapeutic molecules

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124,125 Another example of genetic primary astrocytopathy is the Duchenne muscular dystrophy (DMD) caused by mutations in the gene encoding dystrophin, which in the CNS is present almost exclusively in astrocytes