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Cognitive behavioral therapy remains one of the most well-evidenced approaches for anxiety disorders , according to the American Psychological Association, and it is often paired with medication for moderate to severe cases

Kazunori Nakashima (Organization of Advanced Science and Technology, Kobe University) for their helpful discussion

Constipation is particularly common because slowed gastric emptying means everything moves more slowly through the digestive tract

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May provide different or complementary mechanisms

Additionally, some studies have evaluated outcomes over 12 weeks or longer, though individual responses may vary