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Who Should Not Use GLP-1 Medications: Provider-Guided Exclusions Absolute contraindications include personal history of medullary thyroid carcinoma or MEN 2 syndrome, severe gallbladder disease, uncontrolled diabetic retinopathy, and acute pancreatitis

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In vitro studies have shown that elevating cytoplasmic Ca 2+ with the calcium ionophore A23187 led to a 2.9-fold upregulation of the nuclear-encoded NDUFA9, mitochondrial COX protein, and mitochondrial transcription factor TFAM [239, 240]