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& Richardson, H
(4) Living in a Toxic World: Why We Need Glutathione Every single one of us is exposed to an unprecedented amount of toxins in this day and age
In the absence of adequate GPX4, the radical intermediates, readily produced from hydroperoxy-phospholipids, directly oxidize GSH in a 1-electron reaction to generate a strongly pro-oxidant radical, GSH
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In contrast, GSH depletion drives M1 polarization, resulting in heightened secretion of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1 (Kwon et al., 2019)
The root is the first sensing organ that is initially affected by As exposure [25]
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