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Who should check with a provider first If you are pregnant, nursing, have kidney disease, or take medications that interact with B12 metabolism (such as metformin), discuss this with a provider before starting

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Then the dose can be given every 3-4 days for 2-3 weeks or until complete remission

The absence of safety data in these populations should inform clinical decision-making and prescribing practices

In that case, stop using the product right away (if its a topical, gently wash it off with cool water) and seek prompt medical attention