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Sep 2016;44(6):592-600
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In AP, damage-associated molecular patterns (DAMPs) released from necrotic acinar cells, such as mitochondrial DNA, extracellular ATP, and reactive oxygen species (ROS), which activated NLRP3 inflammasome and resulted in perpetuating a vicious cycle of inflammation, pancreatic necrosis, and systemic inflammatory response syndrome (Papantoniou et al., 2024)
In addition to the idea that chemotherapy must create a lethal injury to DNA to produce malignant cell death is the mechanism of apoptosis
doi: 10.1056/NEJMoa1515920 71 XuW
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