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Depending on how many doses of this DMT a woman has received before becoming pregnant, it might be advisable to introduce natalizumab earlierpossibly even in the third trimesterto try to provide as much continuous coverage with DMT as would be safe for the fetus, while trying to prevent a postpartum rebound
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This targeted mechanism allows enhanced fat oxidation and reduced lipogenesis, particularly in visceral and abdominal fat depots, making it a key subject in obesity and metabolic optimization research
A proportion of patients may experience minimal or no side effects at this stage, while others may notice mild discomfort
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In the 2024 guidelines published by the ESC for PAD management, the authors do not mention GLP-1 RAs as part of management, likely due to limited data at the time [50]
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