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Clin Exp Pharmacol Physiol (2008) 35(12):14339.10.1111/j.1440-1681.2008.05015.x 24 MorrisonMEVijayasaradhiSEngelsteinDAlbinoAPHoughtonAN

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Kidney Impairment Noveltreat 0.25 mg can generally be used in patients with mild to moderate renal impairment

Special considerations : The FDA prescribing information for tirzepatide notes that it may decrease exposure to oral contraceptives, particularly during dose initiation and escalation

Based on animal data, spironolactone may affect sex differentiation of the male during embryogenesis ( 8.1) See 17 for PATIENT COUNSELING INFORMATION

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